Werner+Syndrome+Mutations


 * __Werner Syndrome Location:__**
 * Chromosome 8p12
 * __p12__: shorter hand of the chromosome 12 units away from the centromere (center of the chromosome)

The mutation will occur on the Werner gene. This gene make a protein called RecQ helicase protein. With protein acts as an enzyme "unzipping" DNA; this means the DNA will separate into two strands, and then prepare for the strand of DNA to be replicated in order to succeed cell division. //__(Werner syndrome - Genetics Home Reference)__//

**__Mutation Information:__** There are about 50 mutations that can occur in Werner's Syndrome, and there is still more to be found. There is no specific one that is most common. All the mutations have a frameshift mutation.MORE ON THIS HEREThis means that something from the DNA sequence was inserted differently, or completely deleted. //(__RecQ helicases__)//

__** Conflict With the Protein Affected be The Disorder: **__ A mutated Werner gene can cause a change in the amino acids that are important for the DNA to make the Werner protein. With the Werner's Syndrome there are two possible outcomes. __//(PLoS ONE)//__ These two things can cause many defects in the body. //(Listed in Home Page)//
 * 1) Werner protein has a change in it that causes it to be shortened. This causes it to not make it to the nucleus, and then results in DNA not interacting with the helicase that it needs to "unzip" and then divide.
 * 2) Werner protein has a change in it that causes it to be broken down too quickly. which affects the telomere (end of a chromosome that protects chromosomes from fusing with one-another) by decaying faster than it usually would. This causes manifestation of the disease.